The two kidney to one kidney transition and transplant glomerulopathy: a podocyte perspective

Y Yang, JB Hodgin, F Afshinnia, SQ Wang… - Journal of the …, 2015 - journals.lww.com
The attrition rate of functioning allografts beyond the first year has not improved despite
improved immunosuppression, suggesting that nonimmune mechanisms could be involved.
Notably, glomerulopathies may account for about 40% of failed kidney allografts beyond the
first year of engraftment, and glomerulosclerosis and progression to ESRD are caused by
podocyte depletion. Model systems demonstrate that nephrectomy can precipitate
hypertrophic podocyte stress that triggers progressive podocyte depletion leading to ESRD …