Smad3-mediated upregulation of miR-21 promotes renal fibrosis
X Zhong, ACK Chung, HY Chen… - Journal of the …, 2011 - journals.lww.com
TGF-β/Smad signaling plays a role in fibrogenesis, but therapies targeting TGF-β are
ineffective in treating renal fibrosis. Here, we explored the therapeutic potential of targeting
TGF-β-induced microRNA in the progression of renal fibrosis. Microarray analysis and real-
time PCR revealed upregulation of miR-21 in tubular epithelial cells (TECs) in response to
TGF-β. Lack of Smad3, but not lack of Smad2, prevented cells from upregulating miR-21 in
response to TGF-β. In addition, Smad3-deficient mice were protected from upregulation of …
ineffective in treating renal fibrosis. Here, we explored the therapeutic potential of targeting
TGF-β-induced microRNA in the progression of renal fibrosis. Microarray analysis and real-
time PCR revealed upregulation of miR-21 in tubular epithelial cells (TECs) in response to
TGF-β. Lack of Smad3, but not lack of Smad2, prevented cells from upregulating miR-21 in
response to TGF-β. In addition, Smad3-deficient mice were protected from upregulation of …