Disappearance of T cell-mediated rejection despite continued antibody-mediated rejection in late kidney transplant recipients

PF Halloran, J Chang, K Famulski… - Journal of the …, 2015 - journals.lww.com
The prevalent renal transplant population presents an opportunity to observe the adaptive
changes in the alloimmune response over time, but such studies have been limited by
uncertainties in the conventional biopsy diagnosis of T cell-mediated rejection (TCMR) and
antibody-mediated rejection (ABMR). To circumvent these limitations, we used microarrays
and conventional methods to investigate rejection in 703 unselected biopsies taken 3 days
to 35 years post-transplant from North American and European centers. Using conventional …