[HTML][HTML] Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts
To assess the significance of B-cell and plasma cell infiltrates in renal allografts, we
compared expression of B-cell-associated transcripts (BATs) and immunoglobulin
transcripts (IGTs) to histopathology and function in 177 renal allograft biopsies for clinical
indications. BAT and IGT expression correlated with immunostaining for B cells and plasma
cells and with expression of B-cell and plasma cell transcription factors. BATs and IGTs were
increased in both T-cell-mediated and antibody-mediated rejection. BAT and IGT scores …
compared expression of B-cell-associated transcripts (BATs) and immunoglobulin
transcripts (IGTs) to histopathology and function in 177 renal allograft biopsies for clinical
indications. BAT and IGT expression correlated with immunostaining for B cells and plasma
cells and with expression of B-cell and plasma cell transcription factors. BATs and IGTs were
increased in both T-cell-mediated and antibody-mediated rejection. BAT and IGT scores …