In the Banff consensus, infiltrates in areas of scarring are ignored. This study aimed to
characterize the molecular correlates and clinical significance of scarring and inflammation
in scarred areas. We assessed the extent of interstitial infiltrates, tubulitis and scarring in 129
clinically indicated renal allograft biopsies, and correlated the results with microarray
expression data and allograft survival. Findings were validated in 50 additional biopsies.
Transplants with scarring had a worse prognosis if the scarred area showed infiltrates …