[HTML][HTML] MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA

MJ Scian, DG Maluf, KG David, KJ Archer… - American journal of …, 2011 - Elsevier
Despite the advances in immunosuppression, renal allograft attrition over time remains
unabated due to chronic allograft dysfunction (CAD) with interstitial fibrosis (IF) and tubular
atrophy (TA). We aimed to evaluate microRNA (miRNA) signatures in CAD with IF/TA and
appraise correlation with paired urine samples and potential utility in prospective evaluation
of graft function. MiRNA signatures were established between CAD with IF/TA versus normal
allografts by microarray. Validation of the microarray results and prospective evaluation of …