[HTML][HTML] Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence

J Sellarés, DG De Freitas, M Mengel, J Reeve… - American Journal of …, 2012 - Elsevier
We prospectively studied kidney transplants that progressed to failure after a biopsy for
clinical indications, aiming to assign a cause to every failure. We followed 315 allograft
recipients who underwent indication biopsies at 6 days to 32 years posttransplant. Sixty
kidneys progressed to failure in the follow-up period (median 31.4 months). Failure was rare
after T-cell–mediated rejection and acute kidney injury and common after antibody-mediated
rejection or glomerulonephritis. We developed rules for using biopsy diagnoses, HLA …