[HTML][HTML] Absence of IQGAP1 protein leads to insulin resistance

B Chawla, AC Hedman, S Sayedyahossein… - Journal of Biological …, 2017 - ASBMB
Insulin binds to the insulin receptor (IR) and induces tyrosine phosphorylation of the receptor
and insulin receptor substrate-1 (IRS-1), leading to activation of the PKB/Akt and MAPK/ERK
pathways. IQGAP1 is a scaffold protein that interacts with multiple binding partners and
integrates diverse signaling cascades. Here we show that IQGAP1 associates with both IR
and IRS-1 and influences insulin action. In vitro analysis with pure proteins revealed that the
IQ region of IQGAP1 binds directly to the intracellular domain of IR. Similarly, the …