Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
JC Rodriguez, G Gil-Gómez, FG Hegardt… - Journal of Biological …, 1994 - ASBMB
Fatty acids induce an increase in the transcription of the mitochondrial 3-hydroxy-3-
methylglutaryl-CoA (HMG-CoA) synthase gene, which encodes an enzyme that has been
proposed as a control site of ketogenesis. We studied whether the peroxisome proliferator-
activated receptor (PPAR) is involved in the mechanism of this transcriptional induction. We
found that cotransfection of a rat mitochondrial HMG-CoA synthase promoter-
chloramphenicol acetyltransferase reporter plasmid and a PPAR expression plasmid in the …
methylglutaryl-CoA (HMG-CoA) synthase gene, which encodes an enzyme that has been
proposed as a control site of ketogenesis. We studied whether the peroxisome proliferator-
activated receptor (PPAR) is involved in the mechanism of this transcriptional induction. We
found that cotransfection of a rat mitochondrial HMG-CoA synthase promoter-
chloramphenicol acetyltransferase reporter plasmid and a PPAR expression plasmid in the …