mTOR in aging, metabolism, and cancer
M Cornu, V Albert, MN Hall - Current opinion in genetics & development, 2013 - Elsevier
M Cornu, V Albert, MN Hall
Current opinion in genetics & development, 2013•ElsevierThe target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of
two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular
organisms, TOR regulates cell growth and metabolism in response to nutrients, growth
factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism
and causes age-related disease. This review describes the most recent advances in TOR
signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis …
two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular
organisms, TOR regulates cell growth and metabolism in response to nutrients, growth
factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism
and causes age-related disease. This review describes the most recent advances in TOR
signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis …
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
Elsevier