Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD
S Xavier, R Vasko, K Matsumoto, JA Zullo… - Journal of the …, 2015 - journals.lww.com
Excessive TGF-β signaling in epithelial cells, pericytes, or fibroblasts has been implicated in
CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal
transition. Although several studies focused on the effects of ablating epithelial or fibroblast
TGF-β signaling on development of fibrosis, there is a lack of information on ablating TGF-β
signaling in the endothelium because this ablation causes embryonic lethality. We
generated endothelium-specific heterozygous TGF-β receptor knockout (TβRII endo+/−) …
CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal
transition. Although several studies focused on the effects of ablating epithelial or fibroblast
TGF-β signaling on development of fibrosis, there is a lack of information on ablating TGF-β
signaling in the endothelium because this ablation causes embryonic lethality. We
generated endothelium-specific heterozygous TGF-β receptor knockout (TβRII endo+/−) …