[HTML][HTML] Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium
DR Hill, SP Kessler, HK Rho, MK Cowman… - Journal of Biological …, 2012 - ASBMB
Hyaluronan (HA) is a glycosaminoglycan polymer found in the extracellular matrix of virtually
all mammalian tissues. Recent work has suggested a role for small, fragmented HA
polymers in initiating innate defense responses in immune cells, endothelium, and
epidermis through interaction with innate molecular pattern recognition receptors, such as
TLR4. Despite these advances, little is known regarding the effect of fragmented HA at the
intestinal epithelium, where numerous pattern recognition receptors act as sentinels of an …
all mammalian tissues. Recent work has suggested a role for small, fragmented HA
polymers in initiating innate defense responses in immune cells, endothelium, and
epidermis through interaction with innate molecular pattern recognition receptors, such as
TLR4. Despite these advances, little is known regarding the effect of fragmented HA at the
intestinal epithelium, where numerous pattern recognition receptors act as sentinels of an …