[HTML][HTML] Genetic ablation of calcium-independent phospholipase A2γ (iPLA2γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore …
SH Moon, CM Jenkins, MA Kiebish, HF Sims… - Journal of Biological …, 2012 - ASBMB
Herein, we demonstrate that calcium-independent phospholipase A 2 γ (iPLA 2 γ) is a
critical mechanistic participant in the calcium-induced opening of the mitochondrial
permeability transition pore (mPTP). Liver mitochondria from iPLA 2 γ−/− mice were
markedly resistant to calcium-induced swelling in the presence or absence of phosphate in
comparison with wild-type littermates. Furthermore, the iPLA 2 γ enantioselective inhibitor
(R)-(E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one ((R)-BEL) was …
critical mechanistic participant in the calcium-induced opening of the mitochondrial
permeability transition pore (mPTP). Liver mitochondria from iPLA 2 γ−/− mice were
markedly resistant to calcium-induced swelling in the presence or absence of phosphate in
comparison with wild-type littermates. Furthermore, the iPLA 2 γ enantioselective inhibitor
(R)-(E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one ((R)-BEL) was …