[HTML][HTML] The role of cardiolipin in the structural organization of mitochondrial membranes

M Schlame, M Ren - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2009 - Elsevier
M Schlame, M Ren
Biochimica et Biophysica Acta (BBA)-Biomembranes, 2009Elsevier
Considerable progress has recently been made in understanding the role of cardiolipin in
mitochondria. In this brief review, we discuss new data that show how cardiolipin specifically
contributes to the lateral organization of mitochondrial membranes. We argue that the
function of cardiolipin has to be understood in the context of dynamic membrane assembly
rather than static membrane structure, and we propose that remodeling of cardiolipin, ie the
formation of uniformly substituted molecular species, may reduce the energy barrier of the …
Considerable progress has recently been made in understanding the role of cardiolipin in mitochondria. In this brief review, we discuss new data that show how cardiolipin specifically contributes to the lateral organization of mitochondrial membranes. We argue that the function of cardiolipin has to be understood in the context of dynamic membrane assembly rather than static membrane structure, and we propose that remodeling of cardiolipin, i.e. the formation of uniformly substituted molecular species, may reduce the energy barrier of the assembly process.
Elsevier