[HTML][HTML] Group VIB Ca2+-independent phospholipase A2γ promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other …
M Murakami, S Masuda, K Ueda-Semmyo… - Journal of Biological …, 2005 - ASBMB
Although group VIA Ca 2+-independent phospholipase A 2 β (iPLA 2 β) has been implicated
in various cellular events, the functions of other iPLA 2 isozymes remain largely elusive. In
this study, we examined the cellular functions of group VIB iPLA 2 γ. Lentiviral transfection of
iPLA 2 γ into HEK293 cells resulted in marked increases in spontaneous, stimulus-coupled,
and cell death-associated release of arachidonic acid (AA), which was converted to
prostaglandin E 2 with preferred cyclooxygenase (COX)-1 coupling. Conversely, treatment …
in various cellular events, the functions of other iPLA 2 isozymes remain largely elusive. In
this study, we examined the cellular functions of group VIB iPLA 2 γ. Lentiviral transfection of
iPLA 2 γ into HEK293 cells resulted in marked increases in spontaneous, stimulus-coupled,
and cell death-associated release of arachidonic acid (AA), which was converted to
prostaglandin E 2 with preferred cyclooxygenase (COX)-1 coupling. Conversely, treatment …
