Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

C Crosnier, D Stamataki, J Lewis - Nature Reviews Genetics, 2006 - nature.com
C Crosnier, D Stamataki, J Lewis
Nature Reviews Genetics, 2006nature.com
The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in
the vertebrate body. The renewal process is neatly organized in space, so that the whole
production line, from the ever-youthful stem cells to their dying, terminally differentiated
progeny, is laid out to view in histological sections. A flurry of recent papers has clarified the
key regulatory signals and brought us to the point where we can begin to give a coherent
account, for at least one tissue, of how these signals collaborate to organize the architecture …
Abstract
The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in the vertebrate body. The renewal process is neatly organized in space, so that the whole production line, from the ever-youthful stem cells to their dying, terminally differentiated progeny, is laid out to view in histological sections. A flurry of recent papers has clarified the key regulatory signals and brought us to the point where we can begin to give a coherent account, for at least one tissue, of how these signals collaborate to organize the architecture and behaviour of a stem-cell system.
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