Extracellular vesicles, including exosomes and shed microvesicles (MVs), can be
internalized by recipient cells to modulate function. Although the mechanism by which
extracellular vesicles are internalized is incompletely characterized, it is generally
considered to involve endocytosis and an initial surface-binding event. Furthermore,
modulation of uptake by microenvironmental factors is largely unstudied. Here, we used flow
cytometry, confocal microscopy, and pharmacologic and molecular targeting to address …