Redox regulation of mitochondrial ATP synthase
Reversible cysteine oxidative post-translational modifications (Ox-PTMs) represent an
important mechanism to regulate protein structure and function. In mitochondria, redox
reactions can modulate components of the electron transport chain (ETC), the F1F0 ATP
synthase complex, and other matrix proteins/enzymes. Emerging evidence has linked Ox-
PTMs to mitochondrial dysfunction and heart failure, highlighting some potential therapeutic
avenues. Ox-PTMs can modify a variety of amino acid residues, including cysteine, and …
important mechanism to regulate protein structure and function. In mitochondria, redox
reactions can modulate components of the electron transport chain (ETC), the F1F0 ATP
synthase complex, and other matrix proteins/enzymes. Emerging evidence has linked Ox-
PTMs to mitochondrial dysfunction and heart failure, highlighting some potential therapeutic
avenues. Ox-PTMs can modify a variety of amino acid residues, including cysteine, and …