[HTML][HTML] Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease
R Jagadeeswaran, BA Vazquez, M Thiruppathi… - Experimental …, 2017 - Elsevier
Highlights•Human sickle cell disease (SCD) red blood cells (RBCs) retain
mitochondria.•SCD RBCs with retained mitochondria are associated with excessive reactive
oxygen species.•Mitophagy induction as a treatment for SCD is proposed.Sickle cell disease
(SCD), an inherited blood disorder caused by a point mutation that renders hemoglobin
susceptible to polymerization when deoxygenated, affects millions of people worldwide.
Manifestations of SCD include chronic hemolytic anemia, inflammation, painful vaso …
mitochondria.•SCD RBCs with retained mitochondria are associated with excessive reactive
oxygen species.•Mitophagy induction as a treatment for SCD is proposed.Sickle cell disease
(SCD), an inherited blood disorder caused by a point mutation that renders hemoglobin
susceptible to polymerization when deoxygenated, affects millions of people worldwide.
Manifestations of SCD include chronic hemolytic anemia, inflammation, painful vaso …