Ischemia-reperfusion injury in sickle cell anemia: relationship to acute chest syndrome, endothelial dysfunction, arterial vasculopathy, and inflammatory pain
RP Hebbel - Hematology/oncology Clinics, 2014 - hemonc.theclinics.com
Ischemia-reperfusion (I/R) physiology, also called reperfusion injury, is a fundamental
vascular pathobiological paradigm, which instigates vascular and tissue injury in a variety of
human disease states. This review describes why sickle cell anemia should be
conceptualized in this fashion and how I/R physiology explains the genesis of characteristic
aspects of vascular pathobiology and clinical disease in sickle cell anemia. Disclosures:
Nothing to disclose. Division of Hematology-Oncology-Transplantation, Department of …
vascular pathobiological paradigm, which instigates vascular and tissue injury in a variety of
human disease states. This review describes why sickle cell anemia should be
conceptualized in this fashion and how I/R physiology explains the genesis of characteristic
aspects of vascular pathobiology and clinical disease in sickle cell anemia. Disclosures:
Nothing to disclose. Division of Hematology-Oncology-Transplantation, Department of …