Healing of the inflamed mucosa (mucosal healing) is an emerging new goal for therapy and
predicts clinical remission and resection-free survival in inflammatory bowel diseases
(IBDs). The era of antitumor necrosis factor (TNF) antibody therapy was a remarkable
progress in IBD therapy and anti-TNF agents led to mucosal healing in a subgroup of IBD
patients; however, many patients do not respond to anti-TNF treatment highlighting the
relevance of finding new targets for therapy of IBD. In particular, current studies are …