[HTML][HTML] Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion
J Xu, P Song, S Nakamura, M Miller, S Barone… - Journal of biological …, 2009 - ASBMB
SLC26A7 (human)/Slc26a7 (mouse) is a recently identified chloride-base exchanger and/or
chloride transporter that is expressed on the basolateral membrane of acid-secreting cells in
the renal outer medullary collecting duct (OMCD) and in gastric parietal cells. Here, we show
that mice with genetic deletion of Slc26a7 expression develop distal renal tubular acidosis,
as manifested by metabolic acidosis and alkaline urine pH. In the kidney, basolateral
Cl−/HCO 3− exchange activity in acid-secreting intercalated cells in the OMCD was …
chloride transporter that is expressed on the basolateral membrane of acid-secreting cells in
the renal outer medullary collecting duct (OMCD) and in gastric parietal cells. Here, we show
that mice with genetic deletion of Slc26a7 expression develop distal renal tubular acidosis,
as manifested by metabolic acidosis and alkaline urine pH. In the kidney, basolateral
Cl−/HCO 3− exchange activity in acid-secreting intercalated cells in the OMCD was …