[HTML][HTML] Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand [S]
T Matsunobu, T Okuno, C Yokoyama… - Journal of lipid research, 2013 - ASBMB
12 (S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) has long been considered a by-
product of thromboxane A 2 (TxA 2) biosynthesis with no biological activity. Recently, we
reported 12-HHT to be an endogenous ligand for BLT2, a low-affinity leukotriene B 4
receptor. To delineate the biosynthetic pathway of 12-HHT, we established a method that
enables us to quantify various eicosanoids and 12-HHT using LC-MS/MS analysis. During
blood coagulation, 12-HHT levels increased in a time-dependent manner and were …
product of thromboxane A 2 (TxA 2) biosynthesis with no biological activity. Recently, we
reported 12-HHT to be an endogenous ligand for BLT2, a low-affinity leukotriene B 4
receptor. To delineate the biosynthetic pathway of 12-HHT, we established a method that
enables us to quantify various eicosanoids and 12-HHT using LC-MS/MS analysis. During
blood coagulation, 12-HHT levels increased in a time-dependent manner and were …