Age-related macular degeneration: genetics and biology coming together
LG Fritsche, RN Fariss, D Stambolian… - Annual review of …, 2014 - annualreviews.org
Genetic and genomic studies have enhanced our understanding of complex
neurodegenerative diseases that exert a devastating impact on individuals and society. One
such disease, age-related macular degeneration (AMD), is a major cause of progressive
and debilitating visual impairment. Since the pioneering discovery in 2005 of complement
factor H (CFH) as a major AMD susceptibility gene, extensive investigations have confirmed
19 additional genetic risk loci, and more are anticipated. In addition to common variants …
neurodegenerative diseases that exert a devastating impact on individuals and society. One
such disease, age-related macular degeneration (AMD), is a major cause of progressive
and debilitating visual impairment. Since the pioneering discovery in 2005 of complement
factor H (CFH) as a major AMD susceptibility gene, extensive investigations have confirmed
19 additional genetic risk loci, and more are anticipated. In addition to common variants …
