Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1
A Toda, K Terawaki, S Yamazaki, K Saeki, T Shimizu… - Biochimie, 2010 - Elsevier
Dendritic cells (DCs) are important antigen-presenting cells that control Th1-and Th2-type
immunological reactions by releasing cytokines and interacting directly with T cells.
Leukotriene B4 (LTB4), a classical proinflammatory lipid mediator for phagocytes, was
recently identified as an important attractant for effector CD4+ and CD8+ T cells. However,
little information is available on the roles of LTB4 and its receptor BLT1 in DCs. Here we
show that functional BLT1 expressed in mouse bone marrow-derived DCs (BMDCs) plays …
immunological reactions by releasing cytokines and interacting directly with T cells.
Leukotriene B4 (LTB4), a classical proinflammatory lipid mediator for phagocytes, was
recently identified as an important attractant for effector CD4+ and CD8+ T cells. However,
little information is available on the roles of LTB4 and its receptor BLT1 in DCs. Here we
show that functional BLT1 expressed in mouse bone marrow-derived DCs (BMDCs) plays …