[HTML][HTML] Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation
TH Barker, MA Pallero, MW MacEwen… - Journal of Biological …, 2004 - ASBMB
The hep I peptide of thrombospondin-1 is known to induce the disassembly of focal
adhesions, a critical step in regulating cellular adhesive changes needed for cell motility.
Fibroblasts that are heterogeneous with respect to the surface expression of Thy-1 differ
markedly in morphology, cytoskeletal organization, and migration, suggesting differential
regulation of focal adhesion dynamics. Here we demonstrate that disassembly of focal
adhesions mediated by both full-length thrombospondin-1 and the hep I peptide in …
adhesions, a critical step in regulating cellular adhesive changes needed for cell motility.
Fibroblasts that are heterogeneous with respect to the surface expression of Thy-1 differ
markedly in morphology, cytoskeletal organization, and migration, suggesting differential
regulation of focal adhesion dynamics. Here we demonstrate that disassembly of focal
adhesions mediated by both full-length thrombospondin-1 and the hep I peptide in …