[HTML][HTML] X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor: Comparison with the latent …
O Kleifeld, LP Kotra, DC Gervasi, S Brown… - Journal of Biological …, 2001 - ASBMB
Malignant tumors express high levels of zinc-dependent endopeptidases called matrix
metalloproteinases (MMPs), which are thought to facilitate tumor metastasis and
angiogenesis by hydrolyzing components of the extracellular matrix. Of these enzymes,
gelatinases A (MMP-2) and B (MMP-9), have especially been implicated in malignant
processes, and thus, they have been a target for drugs designed to block their activity.
Therefore, understanding their molecular structure is key for a rational approach to inhibitor …
metalloproteinases (MMPs), which are thought to facilitate tumor metastasis and
angiogenesis by hydrolyzing components of the extracellular matrix. Of these enzymes,
gelatinases A (MMP-2) and B (MMP-9), have especially been implicated in malignant
processes, and thus, they have been a target for drugs designed to block their activity.
Therefore, understanding their molecular structure is key for a rational approach to inhibitor …