[HTML][HTML] Systemic immunity is required for effective cancer immunotherapy

MH Spitzer, Y Carmi, NE Reticker-Flynn, SS Kwek… - Cell, 2017 - Elsevier
MH Spitzer, Y Carmi, NE Reticker-Flynn, SS Kwek, D Madhireddy, MM Martins…
Cell, 2017Elsevier
Immune responses involve coordination across cell types and tissues. However, studies in
cancer immunotherapy have focused heavily on local immune responses in the tumor
microenvironment. To investigate immune activity more broadly, we performed an organism-
wide study in genetically engineered cancer models using mass cytometry. We analyzed
immune responses in several tissues after immunotherapy by developing intuitive models
for visualizing single-cell data with statistical inference. Immune activation was evident in the …
Summary
Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune activation was evident in the tumor and systemically shortly after effective therapy was administered. However, during tumor rejection, only peripheral immune cells sustained their proliferation. This systemic response was coordinated across tissues and required for tumor eradication in several immunotherapy models. An emergent population of peripheral CD4 T cells conferred protection against new tumors and was significantly expanded in patients responding to immunotherapy. These studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.
Elsevier