Thymic function and allogeneic T-cell responses in stem-cell transplantation

KV Komanduri - Cytotherapy, 2002 - Elsevier
The thymus is the primary site of T-cell production early in life, and has now been shown to
continue to function in both healthy and immunocompromised individuals late into life.
Positive and negative selection occurring in the thymus are two of the most important
processes that govern the development and specificity of peripheral T cells, including their
restriction to self HLA and their ability to respond in an alloreactive manner. In the chimeric
state that follows successful allogeneic stem-cell transplants, the specificity of alloreactive …