First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+ CD25+ CD127− T regulatory cells
P Trzonkowski, M Bieniaszewska, J Juścińska… - Clinical …, 2009 - Elsevier
Here, we describe a procedure and first-in-man clinical effects of adoptive transfer of ex vivo
expanded CD4+ CD25+ CD127− T regulatory cells (Tregs) in the treatment of graft versus
host disease (GvHD). The cells were sorted from buffy coats taken from two family donors,
expanded ex vivo and transferred to respective recipients who suffered from either acute or
chronic GvHD. The therapy allowed for significant alleviation of the symptoms and reduction
of pharmacologic immunosuppression in the case of chronic GvHD, while in the case of …
expanded CD4+ CD25+ CD127− T regulatory cells (Tregs) in the treatment of graft versus
host disease (GvHD). The cells were sorted from buffy coats taken from two family donors,
expanded ex vivo and transferred to respective recipients who suffered from either acute or
chronic GvHD. The therapy allowed for significant alleviation of the symptoms and reduction
of pharmacologic immunosuppression in the case of chronic GvHD, while in the case of …