Modelling viral and immune system dynamics

AS Perelson - Nature reviews immunology, 2002 - nature.com
Nature reviews immunology, 2002nature.com
During the past 6 years, there have been substantial advances in our understanding of
human immunodeficiency virus 1 and other viruses, such as hepatitis B virus and hepatitis C
virus, that cause chronic infection. The use of mathematical modelling to interpret
experimental results has made a significant contribution to this field. Mathematical modelling
is also improving our understanding of T-cell dynamics and the quantitative events that
underlie the immune response to pathogens.
Abstract
During the past 6 years, there have been substantial advances in our understanding of human immunodeficiency virus 1 and other viruses, such as hepatitis B virus and hepatitis C virus, that cause chronic infection. The use of mathematical modelling to interpret experimental results has made a significant contribution to this field. Mathematical modelling is also improving our understanding of T-cell dynamics and the quantitative events that underlie the immune response to pathogens.
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