[HTML][HTML] Interferon-γ and donor MHC class I control alternative macrophage activation and activin expression in rejecting kidney allografts: a shift in the Th1-Th2 …
KS Famulski, B Sis, L Billesberger… - American Journal of …, 2008 - Elsevier
Organ allografts deficient in interferon-γ (Ifng) or major histocompatibility complex (MHC)
class I products develop accelerated necrosis when rejection develops, depending on
perforin and granzymes. Thus Ifng-induced donor class I products deliver inhibitory signals
to host inflammatory cells. We used microarrays to investigate whether Ifng-induced donor
class I products also control inflammation patterns in mouse kidney allografts. Compared to
wild-type (WT) allografts, many transcripts were increased in both Ifng-deficient allografts …
class I products develop accelerated necrosis when rejection develops, depending on
perforin and granzymes. Thus Ifng-induced donor class I products deliver inhibitory signals
to host inflammatory cells. We used microarrays to investigate whether Ifng-induced donor
class I products also control inflammation patterns in mouse kidney allografts. Compared to
wild-type (WT) allografts, many transcripts were increased in both Ifng-deficient allografts …