Background Depression, a condition commonly comorbid with multiple sclerosis (MS), is
associated more generally with elevated inflammatory markers and hippocampal pathology.
We hypothesized that neuroinflammation in the hippocampus is responsible for depression
associated with MS. We characterized the relationship between depressive symptoms and
hippocampal microglial activation in patients with MS using the 18-kDa translocator protein
radioligand [18 F] PBR111. To evaluate pathophysiologic mechanisms, we explored the …