RETRACTED: Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year
M Kelleher, A Dunn-Galvin, JOB Hourihane, D Murray… - 2015 - Elsevier
Background Loss-of-function mutations in the skin barrier protein filaggrin (FLG) are a major
risk for atopic dermatitis (AD). The pathogenic sequence of disturbances in skin barrier
function before or during the early development of AD is not fully understood. A more
detailed understanding of these events is needed to develop a clearer picture of disease
pathogenesis. A robust, noninvasive test to identify babies at high risk of AD would be
important in planning early intervention and/or prevention studies. Objectives To ascertain …
risk for atopic dermatitis (AD). The pathogenic sequence of disturbances in skin barrier
function before or during the early development of AD is not fully understood. A more
detailed understanding of these events is needed to develop a clearer picture of disease
pathogenesis. A robust, noninvasive test to identify babies at high risk of AD would be
important in planning early intervention and/or prevention studies. Objectives To ascertain …