Targeting splicing abnormalities in cancer
AA Agrawal, L Yu, PG Smith, S Buonamici - Current opinion in genetics & …, 2018 - Elsevier
AA Agrawal, L Yu, PG Smith, S Buonamici
Current opinion in genetics & development, 2018•ElsevierRecently splicing has been recognized as a key pathway in cancer. Although aberrant
splicing has been shown to be a consequence of mutations or the abnormal expression of
splicing factors (trans-effect changes) or mutations in the splicing sequences (cis-effect
mutations), the connections between aberrant splicing and cancer initiation or progression
are still not well understood. Here we review the mutational landscape of splicing factors in
cancer and associated splicing consequences, along with the most important examples of …
splicing has been shown to be a consequence of mutations or the abnormal expression of
splicing factors (trans-effect changes) or mutations in the splicing sequences (cis-effect
mutations), the connections between aberrant splicing and cancer initiation or progression
are still not well understood. Here we review the mutational landscape of splicing factors in
cancer and associated splicing consequences, along with the most important examples of …
Recently splicing has been recognized as a key pathway in cancer. Although aberrant splicing has been shown to be a consequence of mutations or the abnormal expression of splicing factors (trans-effect changes) or mutations in the splicing sequences (cis-effect mutations), the connections between aberrant splicing and cancer initiation or progression are still not well understood.
Here we review the mutational landscape of splicing factors in cancer and associated splicing consequences, along with the most important examples of the therapeutic approaches targeting the spliceosome currently being investigated in oncology.
Elsevier