Convergence of bladder and colon sensory innervation occurs at the primary afferent level
JA Christianson, R Liang, EE Ustinova, BM Davis… - Pain, 2007 - Elsevier
Dichotomizing afferents are individual dorsal root ganglion (DRG) neurons that innervate
two distinct structures thereby providing a form of afferent convergence that may be involved
in pelvic organ cross-sensitization. To determine the distribution of dichotomizing afferents
supplying the distal colon and bladder of the Sprague–Dawley rat and the C57Bl/6 mouse,
we performed concurrent retrograde labeling of urinary bladder and distal colon afferents
using cholera toxin subunit B (CTB) fluorescent conjugates. Animals were perfused 4–5 …
two distinct structures thereby providing a form of afferent convergence that may be involved
in pelvic organ cross-sensitization. To determine the distribution of dichotomizing afferents
supplying the distal colon and bladder of the Sprague–Dawley rat and the C57Bl/6 mouse,
we performed concurrent retrograde labeling of urinary bladder and distal colon afferents
using cholera toxin subunit B (CTB) fluorescent conjugates. Animals were perfused 4–5 …