[HTML][HTML] Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial …
Invariant natural killer T (iNKT) cells are non-conventional lipid-reactive αβ T lymphocytes
that play a key role in host responses during viral infections, in particular through the swift
production of cytokines. Their beneficial role during experimental influenza A virus (IAV)
infection has recently been proposed, although the mechanisms involved remain elusive.
Here we show that during in vivo IAV infection, mouse pulmonary iNKT cells produce IFN-γ
and IL-22, a Th17-related cytokine critical in mucosal immunity. Although permissive to viral …
that play a key role in host responses during viral infections, in particular through the swift
production of cytokines. Their beneficial role during experimental influenza A virus (IAV)
infection has recently been proposed, although the mechanisms involved remain elusive.
Here we show that during in vivo IAV infection, mouse pulmonary iNKT cells produce IFN-γ
and IL-22, a Th17-related cytokine critical in mucosal immunity. Although permissive to viral …