[HTML][HTML] CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates
Costimulatory blockade with anti-CD154 monoclonal antibody (aCD154) prolongs allograft
survival in nonhuman primates, but has not reliably induced tolerance when used alone. In
the current studies, we evaluated the effect of adding CD154 blockade to a chimerism
inducing nonmyeloablative regimen in primates. We observed a significant improvement of
donor bone marrow (DBM) engraftment, which has been associated with a lower incidence
of acute rejection and long-term survival of renal allografts without the need for previously …
survival in nonhuman primates, but has not reliably induced tolerance when used alone. In
the current studies, we evaluated the effect of adding CD154 blockade to a chimerism
inducing nonmyeloablative regimen in primates. We observed a significant improvement of
donor bone marrow (DBM) engraftment, which has been associated with a lower incidence
of acute rejection and long-term survival of renal allografts without the need for previously …
