[HTML][HTML] An anti-CD154 domain antibody prolongs graft survival and induces Foxp3+ iTreg in the absence and presence of CTLA-4 Ig
DF Pinelli, ME Wagener, D Liu, A Yamniuk… - American Journal of …, 2013 - Elsevier
The use of monoclonal antibodies targeting the CD154 molecule remains one of the most
effective means of promoting graft tolerance in animal models, but thromboembolic
complications during early clinical trials have precluded their use in humans. Furthermore,
the role of Fc-mediated deletion of CD154-expressing cells in the observed efficacy of these
reagents remains controversial. Therefore, determining the requirements for anti-CD154-
induced tolerance will instruct the development of safer but equally efficacious treatments …
effective means of promoting graft tolerance in animal models, but thromboembolic
complications during early clinical trials have precluded their use in humans. Furthermore,
the role of Fc-mediated deletion of CD154-expressing cells in the observed efficacy of these
reagents remains controversial. Therefore, determining the requirements for anti-CD154-
induced tolerance will instruct the development of safer but equally efficacious treatments …
