Presence of FoxP3+ regulatory T cells predicts outcome of subclinical rejection of renal allografts
O Bestard, JM Cruzado, J Torras, M Goma… - Journal of the …, 2008 - journals.lww.com
Subclinical rejection (SCR) of renal allografts refers to histologic patterns of acute rejection
despite stable renal function. The clinical approach to SCR is controversial; it would be
helpful to identify biomarkers that could determine whether the identified cellular infiltrates
were detrimental. For investigation of whether the presence of FoxP3+ regulatory T cells
(Treg) could help determine the functional importance of tubulointerstitial infiltrates observed
in 6-mo protocol biopsies, 37 cases of SCR were evaluated. The presence of FoxP3+ Treg …
despite stable renal function. The clinical approach to SCR is controversial; it would be
helpful to identify biomarkers that could determine whether the identified cellular infiltrates
were detrimental. For investigation of whether the presence of FoxP3+ regulatory T cells
(Treg) could help determine the functional importance of tubulointerstitial infiltrates observed
in 6-mo protocol biopsies, 37 cases of SCR were evaluated. The presence of FoxP3+ Treg …