[HTML][HTML] Tolerance of lung allografts achieved in nonhuman primates via mixed hematopoietic chimerism
M Tonsho, S Lee, A Aoyama, S Boskovic… - American Journal of …, 2015 - Elsevier
While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts
in nonhuman primates and patients, this approach has not been successful for more
immunogenic organs. Here, we describe a modified delayed-tolerance-induction protocol
resulting in three out of four monkeys achieving long-term lung allograft survival without
ongoing immunosuppression. Two of the tolerant monkeys displayed stable mixed lymphoid
chimerism, and the other showed transient chimerism. Serial biopsies and post-mortem …
in nonhuman primates and patients, this approach has not been successful for more
immunogenic organs. Here, we describe a modified delayed-tolerance-induction protocol
resulting in three out of four monkeys achieving long-term lung allograft survival without
ongoing immunosuppression. Two of the tolerant monkeys displayed stable mixed lymphoid
chimerism, and the other showed transient chimerism. Serial biopsies and post-mortem …