Depletion of gut microbiota protects against renal ischemia-reperfusion injury

D Emal, E Rampanelli, I Stroo, LM Butter… - Journal of the …, 2017 - journals.lww.com
An accumulating body of evidence shows that gut microbiota fulfill an important role in
health and disease by modulating local and systemic immunity. The importance of the
microbiome in the development of kidney disease, however, is largely unknown. To study
this concept, we depleted gut microbiota with broad-spectrum antibiotics and performed
renal ischemia-reperfusion (I/R) injury in mice. Depletion of the microbiota significantly
attenuated renal damage, dysfunction, and remote organ injury and maintained tubular …