Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection
A Chancellor, A White, AS Tocheva, JR Fenn… - Tuberculosis, 2017 - Elsevier
Correlates of immune protection that reliably predict vaccine efficacy against Mycobacterium
tuberculosis (Mtb) infection are urgently needed. Invariant NKT cells (iNKTs) are CD1d-
dependent innate T cells that augment host antimicrobial immunity through production of
cytokines, including interferon (IFN)-γ and tumour necrosis factor (TNF)-α. We determined
peripheral blood iNKT numbers, their proliferative responses and iNKT subset proportions
after in vitro antigen expansion by α-galactosylceramide (αGC) in a large cohort of …
tuberculosis (Mtb) infection are urgently needed. Invariant NKT cells (iNKTs) are CD1d-
dependent innate T cells that augment host antimicrobial immunity through production of
cytokines, including interferon (IFN)-γ and tumour necrosis factor (TNF)-α. We determined
peripheral blood iNKT numbers, their proliferative responses and iNKT subset proportions
after in vitro antigen expansion by α-galactosylceramide (αGC) in a large cohort of …
