[HTML][HTML] Omental adipose tissue fibrosis and insulin resistance in severe obesity
V Guglielmi, M Cardellini, F Cinti, F Corgosinho… - Nutrition & …, 2015 - nature.com
V Guglielmi, M Cardellini, F Cinti, F Corgosinho, I Cardolini, M D'adamo, MC Zingaretti…
Nutrition & diabetes, 2015•nature.comResults: Fibrosis at morphological level resulted significantly greater in Group B compared
with Group A, although collagens gene expression did not differ. Notably, collagen VI
messenger RNA significantly correlated with collagen I, collagen III, HIF-1α, TGF-β1, CD68,
MCP-1 and CD86 transcription levels, supporting their relation with fibrosis development.
Conclusions: In conclusion, we show for the first time that human oWAT fibrosis in severe
obesity is consistent with a higher degree of insulin resistance measured by glucose clamp …
with Group A, although collagens gene expression did not differ. Notably, collagen VI
messenger RNA significantly correlated with collagen I, collagen III, HIF-1α, TGF-β1, CD68,
MCP-1 and CD86 transcription levels, supporting their relation with fibrosis development.
Conclusions: In conclusion, we show for the first time that human oWAT fibrosis in severe
obesity is consistent with a higher degree of insulin resistance measured by glucose clamp …
Results:
Fibrosis at morphological level resulted significantly greater in Group B compared with Group A, although collagens gene expression did not differ. Notably, collagen VI messenger RNA significantly correlated with collagen I, collagen III, HIF-1α, TGF-β1, CD68, MCP-1 and CD86 transcription levels, supporting their relation with fibrosis development.
Conclusions:
In conclusion, we show for the first time that human oWAT fibrosis in severe obesity is consistent with a higher degree of insulin resistance measured by glucose clamp. Therefore, collagen deposition could represent a maladaptive mechanism contributing to obesity-related metabolic complications.
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