Cardiac hypertrophy and associated heart fibrosis remain a major cause of death worldwide.
Phytochemicals have gained attention as alternative therapeutics for managing
cardiovascular diseases. These include the extract from the plant Terminalia arjuna, which is
a popular cardioprotectant and may prevent or slow progression of pathological hypertrophy
to heart failure. Here, we investigated the mode of action of a principal bioactive T. arjuna
compound, arjunolic acid (AA), in ameliorating hemodynamic load-induced cardiac fibrosis …