Introduction to a review series on chronic GVHD: from pathogenic B-cell receptor signaling to novel therapeutic targets
R Zeiser, RS Negrin - Blood, The Journal of the American …, 2017 - ashpublications.org
R Zeiser, RS Negrin
Blood, The Journal of the American Society of Hematology, 2017•ashpublications.orgChronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic
hematopoietic cell transplantation. Over the last decade, clinical success in patients with
cGVHD has been hampered by the lack of insight into the complex pathobiological
mechanisms of the disease, the paucity of specific therapeutic targets, and the need for a
commonly accepted diagnostic staging system for response assessment. In this review
series, leading authors in the field present and discuss novel findings in basic T-and B-cell …
hematopoietic cell transplantation. Over the last decade, clinical success in patients with
cGVHD has been hampered by the lack of insight into the complex pathobiological
mechanisms of the disease, the paucity of specific therapeutic targets, and the need for a
commonly accepted diagnostic staging system for response assessment. In this review
series, leading authors in the field present and discuss novel findings in basic T-and B-cell …
Chronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic hematopoietic cell transplantation. Over the last decade, clinical success in patients with cGVHD has been hampered by the lack of insight into the complex pathobiological mechanisms of the disease, the paucity of specific therapeutic targets, and the need for a commonly accepted diagnostic staging system for response assessment.
In this review series, leading authors in the field present and discuss novel findings in basic T-and B-cell biology research that have led to novel therapeutic targets in cGVHD, 1 mechanistic approaches for prevention and treatment of cGVHD, 2 and a summary of the National Institutes of Health (NIH) Consensus Development Projects on Criteria for Clinical Trials in cGVHD; they then put these concepts into the clinical context. 3
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