Statins, mevalonate pathway and its intermediate products in placental development and preeclampsia
L Ermini, M Post, I Caniggia - Current Molecular Pharmacology, 2017 - ingentaconnect.com
L Ermini, M Post, I Caniggia
Current Molecular Pharmacology, 2017•ingentaconnect.comCurrent Molecular Pharmacology Page 1 Current Molecular Pharmacology ISSN: 1874-4672
eISSN: 1874-4702 BENTHAM SCIENCE Leonardo Ermini1, Martin Post1,2 and Isabella
Caniggia2,3,* 1Physiology and Experimental Medicine Program, The Hospital for Sick Children,
Toronto, Ontario, Canada; 2Department of Physiology, University of Toronto, Toronto, Ontario,
Canada; 3The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto,
Ontario, Canada ARTICLEHISTORY Received: August 12, 2015 Revised: October 25, 2015 …
eISSN: 1874-4702 BENTHAM SCIENCE Leonardo Ermini1, Martin Post1,2 and Isabella
Caniggia2,3,* 1Physiology and Experimental Medicine Program, The Hospital for Sick Children,
Toronto, Ontario, Canada; 2Department of Physiology, University of Toronto, Toronto, Ontario,
Canada; 3The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto,
Ontario, Canada ARTICLEHISTORY Received: August 12, 2015 Revised: October 25, 2015 …
The mevalonate pathway synthesizes intermediates and products such as cholesterol and nonsterol isoprenoids that are crucial for cell survival and function. In the human placenta, the prenylation of proteins, rather than cholesterol synthesis, represents the main
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