Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: possible …
Introduction A hallmark of preeclampsia is endothelial cell dysfunction/activation in response
to “toxins” from the placenta. Necrotic trophoblastic debris (NTD) is one possible placental
toxin and others include inflammatory cytokines. Calcium supplementation appears to
protect “at-risk” women from developing preeclampsia by an unknown mechanism. In this
study we investigate whether the addition of high levels of calcium to endothelial cells prior
to their exposure to the preeclampsia-associated activators could reduce the endothelial cell …
to “toxins” from the placenta. Necrotic trophoblastic debris (NTD) is one possible placental
toxin and others include inflammatory cytokines. Calcium supplementation appears to
protect “at-risk” women from developing preeclampsia by an unknown mechanism. In this
study we investigate whether the addition of high levels of calcium to endothelial cells prior
to their exposure to the preeclampsia-associated activators could reduce the endothelial cell …