Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia

SC Tidwell, HN Ho, WH Chiu, RJ Torry… - American journal of …, 2001 - Elsevier
Objective: Maternal serum placenta growth factor levels have been shown to be significantly
reduced in women with established preeclampsia. However, the temporal change in serum
placenta growth factor levels before the clinical onset of preeclampsia is not known. Study
Design: Serum samples were collected from patients at the first prenatal (5-15 weeks'
gestation), second-trimester (16-20 weeks' gestation), and third-trimester (26-30 weeks'
gestation) visits. Serum placenta growth factor levels were determined and analyzed …