Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through
changes in its trafficking, membrane expression and open probability. Plasma levels of
aldosterone are decreased in preeclampsia. Herein we postulated that if aldosterone
regulates ENaC expression then its expression should be decreased in preeclampsia. We
found a diminished expression of the three subunits of the ENaC in the membranes of
preeclamptic placentas in comparison with the normal ones. Although the role of ENaC in …